At Melbourne Stem Cell Centre we believe that publishing our results adds to the body of stem cell research in the hope that in the future this treatment will become more widely accessible and accepted. We have a list of our published papers. We have copies of these in the clinic for our patients to read, and for those that are open access we have added a resource page on the website.
Knee Trial 2018
Melbourne Stem Cell Centre in partnership with Magellan Stem Cells are embarking on further research to assess the safety and benefit of donor stem cell therapy for knee osteoarthritis. The recruitment for this trial has now finished.
We hope to have results available on this trial in the next 12-18 months. If you would like to stay up to date with the results of the research sign up to the joint pain email list.
Recent advancement in our understanding of the pathological disease process of degenerative musculoskeletal conditions including osteoarthritis has seen increased interest in the area of regenerative therapies.
There exists significant animal and human research in the clinical application of stem cell therapies for osteoarthritis.
Cartilage regeneration has been shown in animal models with cartilage defects after treatment with stem cells (Dragoo et al. 2007; Cui et al. 2009). Further, well controlled trials have shown a significant improvement in lameness and range of motion in dogs following stem cell injections (Black et al, 2007, Black et al 2008).
In human research, there is growing evidence of success in the treatment of osteoarthritis. Reported case studies of bone marrow derived mesenchymal stem cell injections for symptomatic hip and knee osteoarthritis have shown improvement in pain and function (Centeno et al, 2006, Centeno et al, 2008, Pak 2011; Davachi et al. 2011; Emadedin et al, 2011).
A recently published strictly controlled trial involving the use of peripheral blood stem cells in combination with arthroscopic surgery of knee cartilage lesions has shown significant improvement in the quality of cartilage repair (Saw et al. 2013).
There are now close to 400 trials using mesenchymal stem cells registered with the National Institutes of Health. Over 30 of these are focused on musculoskeletal disease and most of these are treating osteoarthritis.
A recent review of trials involving a total of 1012 participants receiving stem cell therapy for various clinical conditions including Ischaemic Stroke, Crohn’s disease, cardiomyopathy, Ischaemic Heart Disease and graft versus host disease, did not identify any significant adverse events other than transient elevation of temperature/fever (Lalu et al, 2012).
Awad HA, et al. Autologous mesenchymal stem cell-mediated repair of tendon. 1999; 5(3): 267-277
Diekman B, et al. Chondrogenesis of Adult Stem Cells from Adipose Tissue and Bone Marrow: Induction by Growth Factors and Cartilage Matrix. Tissue Eng. 2010; 16(2):523-533
Dragoo J, et al. Healing full-thickness cartilage defects using adipose-derived stem cells. Tissue Eng. 2007; 13(7):1615-1621.
Jo, CH., Lee, Y., et al. (2014). “ Intra-articular injection of mesenchymal stem cells for the treatment of osteoarthritis of the knee: A proof of concept clinical trial.’ Stem Cells: Doi: 10.1002/stem.1634
Krampera M, et al. Mesenchymal stem cells for bone, cartilage, tendon and skeletal muscle repair. Bone. 2006; 39(4): 678-683
Lalu, ML., McIntyre, L., et al. (2012) “ Safety of cell therapy with mesenchymal stromal cells (safe cell): A systematic review and meta-analysis of clinical trials”, PLOS One; 7(10), open access e47559
Peeters, CM., Leijs, MJ., et al. (2013) “Safety of intra-articular cell-therapy with culture-expanded stem cells in humans: a systematic literature review” Osteo Cartilage; 21(10): 1465-1473.
Pittinger MF, et al. Multilineage potential of adult human mesenchymal stem cells. Science. 1999; 284(5411): 143-147
Saw KY, et al. Articular cartilage regeneration with autologous peripheral blood progenitor cells and hyaluronic acid after arthroscopic subchondral drilling: A report of 5 cases with histology. J Arthroscopic and Rel Surg. 2011; 27(4):493-506.
Tuan RS, et al. Adult mesenchymal stem cells and cell-based tissue engineering. Arth Res Ther. 2003; 5(1): 32-35
Uysal AC, et al. Tendon regeneration and repair with adipose derived stem cells. Curr Stem Cell Res Ther. 2010; 5(2): 161-167
Wakitani S, et al. Repair of articular cartilage defects in the patello-femoral joint with autologous bone marrow mesenchymal cell transplantation: three case reports involving nine defects of five knees. J Tissue Eng Regen Med. 2007; 1(1):74-79.
Wakitani S, et al. Safety of autologous bone marrrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months. J Tissue Eng Regen Med. 2011; 5(2):146-150.
Young RG, et al. Use of mesenchymal stem cells in a collagen matrix for achilles tendon repair. J Orth Res. 1998; 16(4): 406-413